Protein Domain : IPR016075

Type:  Domain Name:  RNA polymerase, phosphoprotein P, C-terminal XD, paramyxovirinae
Description:  Paramyxovirinae has a negative-sense ssRNA genome that is packaged by the viral nucleoprotein (N) within a helical nucleocapsid. The N-RNA (nucleoprotein-RNA) complex is used as a template for both transcription and replication. During viral genome replication, the synthesis of viral RNA and its encapsidation by N are concomitant. Viral transcription and replication are carried out by viral RNA-dependent RNA polymerase, which consists of two proteins: L polymerase and phosphoprotein P. The L polymerase carries the enzyme activity. Phosphoprotein P binds the viral nucleocapsid, and positions the L polymerase on the template for transcription and replication formed by nucleoprotein-RNA (N-RNA). Phosphoprotein P, an indispensable subunit of the viral polymerase complex, is a modular protein organised into two moieties that are both functionally and structurally distinct: a well-conserved C-terminal moiety that contains all the regions required for transcription, and a poorly conserved, intrinsically unstructured N-terminal moiety that provides several additional functions required for replication. The N-terminal moiety is responsible for binding to newly synthesized free N(0) (nucleoprotein that has not yet bound RNA), in order to prevent the binding of N(0) to cellular RNA. The C-terminal moiety consists of an oligomerisation domain, an N-RNA (nucleoprotein-RNA)-binding domain and an L polymerase-binding domain. This entry represents the XD domain found at the extreme C-terminal of the C-terminal moiety of phosphoprotein P from several Paramyxovirinae, including Measles virus[, ], Canine distemper virusand Sendai virus[, , ]. Short Name:  RNA_pol_Pprot-P_XD_paramyxovir
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0 Child Features

0 Contains

1 Cross References

Identifier
SSF101089

2 Found Ins

DB identifier Type Name
IPR002693 Domain Paramyxovirinae P phosphoprotein C-terminal domain
IPR004897 Family P/V phosphoprotein, paramyxoviral

4 GO Annotations

GO Term Gene Name
GO:0003723 IPR016075
GO:0003968 IPR016075
GO:0006351 IPR016075
GO:0019079 IPR016075

4 Ontology Annotations

GO Term Gene Name
GO:0003723 IPR016075
GO:0003968 IPR016075
GO:0006351 IPR016075
GO:0019079 IPR016075

0 Parent Features

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm_27.model.AmTr_v1.0_scaffold00160.32 W1PT16 PAC:31575641 Amborella trichopoda 144  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10400742
            12944395
            15159535
            14980481
            17459940