Protein Domain : IPR029784

Type:  Family Name:  Iron regulatory protein 1
Description:  In mammals, iron regulatory proteins (IRPs) 1 and 2 posttranscriptionally regulate expression of genes involved in iron metabolism by binding mRNA motifs called iron responsive elements (IREs) []. IRP1 is a bifunctional protein that also has aconitase activity. IRP1 mostly exists in a non-IRE-binding, [4Fe-4S]cluster aconitase form which predominates when iron levels are normal; but if levels drop sufficiently the disassembly of the [4Fe-4S]-cluster occurs and there is a change of conformation to the IRE-binding form. On the other hand, IRP2 does not assemble an Fe-S cluster, lacks aconitase activity, and spontaneously binds IREs []. Since IRP1 is predominantly in the enzymatic cytoplasmic aconitase form, it is IRP2 that acts as the major metabolic regulator that maintains iron homeostasis [].This entry represents iron regulatory protein 1, also known as iron-responsive element-binding protein 1 (IRE-BP1) or cytoplasmic aconitate hydratase []. Short Name:  IRE-BP1
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR11670:SF32

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003994 IPR029784
GO:0051539 IPR029784
GO:0006879 IPR029784
GO:0010040 IPR029784

4 Ontology Annotations

GO Term Gene Name
GO:0003994 IPR029784
GO:0051539 IPR029784
GO:0006879 IPR029784
GO:0010040 IPR029784

1 Parent Features

DB identifier Type Name
IPR006249 Family Aconitate/Iron-responsive element-binding protein 2

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
GlymaFiskIII.02G167300.1.p PAC:50793700 Glycine max Fiskeby 95  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16850017
            21566147
            20603012
            8041788