Protein Domain : IPR012838

Type:  Family Name:  Pyruvate formate-lyase activating enzyme
Description:  Pyruvate formate lyase-activating enzyme is a 28 kDa monomeric protein which is involved in the anerobic glucose metabolism pathway. It is a member of the radical S-adenosylmethionine family of enzymes which initiate radical catalysis. It is necessary to activate pyruvate formate lyase (PFL), which catalyses the conversion of pyruvate and coenzyme A to formate and acetyl CoA.Pyruvate formate lyase activating enzyme functions by catalysing the formation of the Gly734 radical of PFL. It utilises a [4Fe-4S] cluster and adenosylmethionine to generate a putative adenosyl radical, which extracts a hydrogen atom from Gly734 on PFL, thus activating PFL for catalysis []. Members of this family are iron-sulphur proteins with a radical-SAM domain. Short Name:  PFL_activating
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0 Child Features

2 Contains

DB identifier Type Name
IPR007197 Domain Radical SAM
IPR001989 Conserved_site Radical-activating enzyme, conserved site

1 Cross References

Identifier
TIGR02493

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0043365 IPR012838
GO:0055114 IPR012838

2 Ontology Annotations

GO Term Gene Name
GO:0043365 IPR012838
GO:0055114 IPR012838

0 Parent Features

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Vocar.0013s0178.1.p PAC:32896419 Volvox carteri 341  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15581584