3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0015379 | IPR000076 |
| GO:0006811 | IPR000076 |
| GO:0016021 | IPR000076 |
| Type: | Family | Name: | K/Cl co-transporter |
| Description: | K+Cl- cotransporters (KCCs) belong to the SLC12 family and act as electroneutral symporters of K+ and Cl- ions across the plasma membrane [, ]. They are major determinants of osmotic homeostasis. They are involved in the regulatory volume decrease in response to cell swelling inred blood cells, and have been proposed to play a role in the vectorial movement of Cl-across kidney epithelia. The transport process involves one for one electroneutral movement of K+together with Cl-, and, in all known mammalian cells, the net movement is outward [].In neurones, it appears to play a unique role in maintaining low intracellular Cl-concentration, which is required for the functioning of Cl-dependent fast synaptic inhibition, mediated by certain neurotransmitters, such as gamma-aminobutyric acid (GABA) and glycine.Four isoforms of KCC have been identified: KCC1, KCC2, KCC3, and KCC4. The four KCC isoforms share a common protein structure with a central core of twelve hydrophobic transmembrane domains []. Comparison of their sequences with those of otherion-transporting membrane proteins reveals that they are part of a new superfamily of cation-chloride co-transporters, which includes the Na-Cl andNa-K-2Cl co-transporters. KCC1 is widely expressed in human tissues, while KCC2 is expressed only in brain neurones, making it likely that this is theisoform responsible for maintaining low Cl-concentration in neurones [, ]. | Short Name: | KCL_cotranspt |
| GO Term | Gene Name |
|---|---|
| GO:0015379 | IPR000076 |
| GO:0006811 | IPR000076 |
| GO:0016021 | IPR000076 |
