Type: | Domain | Name: | Peptide N glycanase, PAW domain |
Description: | The PAW domain (present in PNGases and other worm proteins) is found as a single copy at the C terminus of metazoan peptide:N-glycanase (PNGase)and in multiple copies in hypothetical Caenorhabditis elegansproteins peptide:N-glycanases (PNGases) []. The C-terminal PAW domain of PNGase binds to the mannose moieties of N-linked oligosaccharide chains [].The PAW domain is a slightly elongated molecule and displays a beta-sandwich architecture, which is composed of two layers, containing nine and eightantiparallel beta-strands, respectively, and three additional short helices [].Some proteins known to contain a PAW domain are listed below:Animal peptide:N-glycanase (PNGase) , catalyses the deglycosylation of several misfolded N-linked glycoproteins by cleaving thebulky glycan chain before the proteins are degraded by the proteasome. Caenorhabditis elegansputative uncharacterised protein C17B7.5. | Short Name: | Peptide_N_glycanase_PAW_dom |