4 GO Annotations
| GO Term | Gene Name |
|---|---|
| GO:0005388 | IPR030320 |
| GO:0005524 | IPR030320 |
| GO:0070588 | IPR030320 |
| GO:0016021 | IPR030320 |
4 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0005388 | IPR030320 |
| GO:0005524 | IPR030320 |
| GO:0070588 | IPR030320 |
| GO:0016021 | IPR030320 |
| Type: | Family | Name: | Plasma membrane calcium-transporting ATPase 1 |
| Description: | Plasma membrane calcium-transporting ATPase 1 (ATP2B1, also known as PMCA1) belongs to the IIB subfamily of P-type ATPases, whose members are plasma membrane Ca2+ ATPases (PMCAs) that catalyse the hydrolysis of ATP coupled with the transport of calcium []. ATP2B1 is widely expressed in animal tissues during development []. Its auto-inhibitory C-terminal tail can be cleaved by a protease-calpain []. This activation by calpain may have a role in the activation of erythrocytes []. In breast cancer cells, ATP2B1 regulates cell death pathways in the presence of cell death stimuli []. It may also represent one of the sites of action of maitotoxin (MTX), one of the most potent toxins produced by the "red-tide" dinoflagellate Gambierdiscus toxicus. MTX-induced currents are significantly reduced by knockdown of ATP2B1, and the toxin may bind to and convert the PMCA pump into a Ca(2+)-permeable nonselective cation channel []. | Short Name: | ATP2B1 |
| GO Term | Gene Name |
|---|---|
| GO:0005388 | IPR030320 |
| GO:0005524 | IPR030320 |
| GO:0070588 | IPR030320 |
| GO:0016021 | IPR030320 |
| GO Term | Gene Name |
|---|---|
| GO:0005388 | IPR030320 |
| GO:0005524 | IPR030320 |
| GO:0070588 | IPR030320 |
| GO:0016021 | IPR030320 |
