1 Found In
| DB identifier | Type | Name |
|---|---|---|
| IPR003951 | Family | Peptidase C58, Yersinia/Haemophilus virulence surface antigen |
| Type: | Domain | Name: | Peptidase C58, YopT-type domain |
| Description: | This group of sequences are characterised by a cysteine protease domain, corresponding to MEROPS peptidase family C58 (clan CA), found in proteins of bacteria that include plant pathogens (Pseudomonas syringae), root nodule bacteria, and intracellular pathogens (e.g. Yersinia pestis, Haemophilus ducreyi, Pasteurella multocida, Chlamydia trachomatis) of animal hosts. The domain features a catalytic triad of Cys, His, and Asp. Sequences can be extremely divergent outside of a few well-conserved motifs. YopT, a virulence effector protein of Y. pestis, cleaves and releases host cell Rho GTPases from the membrane, thereby disrupting the actin cytoskeleton. Members of the family from pathogenic bacteria are likely to be pathogenesis factors []. | Short Name: | Peptidase_C58_Yopt |
| DB identifier | Type | Name |
|---|---|---|
| IPR003951 | Family | Peptidase C58, Yersinia/Haemophilus virulence surface antigen |
