3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0070915 | IPR005385 |
| GO:0007186 | IPR005385 |
| GO:0016021 | IPR005385 |
| Type: | Family | Name: | Lysophosphatidic acid receptor EDG-7 |
| Description: | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [, , ].The G protein-coupled receptors EDG-2, EDG-4 and EDG-7 have now been identified as high affinity receptors for lysophosphatidic acid (LPA). EDG-7 is expressed at high levels in the testis, prostate, heart, pancreas and frontal cerebral cortex in humans and at lower levels in the intestine, lung and ovary. Binding of LPA to the receptor leads to increased cyclic AMP and calcium levels and activation of MAP kinases. It is believed that these effects are mediated by Gq and possibly Gi class proteins []. EDG-7 does not appear to be able to couple to G1. | Short Name: | LPA_rcpt_EDG7 |
| GO Term | Gene Name |
|---|---|
| GO:0070915 | IPR005385 |
| GO:0007186 | IPR005385 |
| GO:0016021 | IPR005385 |
