3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0016783 | IPR003720 |
| GO:0034227 | IPR003720 |
| GO:0005737 | IPR003720 |
| Type: | Family | Name: | tRNA sulfurtransferase ThiI |
| Description: | tRNA sulfurtransferase ThiI catalyses the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor [, , ]. In some bacteria, ThiI is a bifunctional enzyme required for the synthesis of both the 4-thiouridine modification in tRNA and the thiazole moiety in the thiamine biosynthesis pathway [].Three domains of ThiI are essential for the thiolation of tRNA: a THUMP domain that binds tRNA (see ) [], an AANH domain that activates the uridine residue by adenylylation [], and a rhodanese domain that transfers sulfur to the activated uridine residue []. Neither the THUMP nor the AANH domain of ThiI are essential for thiamine synthesis, only the rhodanese domain is necessary for synthesis of the thiazole moiety of thiamine []. | Short Name: | tRNA_STrfase |
| GO Term | Gene Name |
|---|---|
| GO:0016783 | IPR003720 |
| GO:0034227 | IPR003720 |
| GO:0005737 | IPR003720 |
