Protein Domain : IPR003005

Type:  Family Name:  Amphiphysin
Description:  Amphiphysins belong to the expanding BAR (Bin-Amphiphysin-Rvsp) family proteins, all members of which share a highly conserved N-terminal BAR domain, which has predicted coiled-coil structures required for amphiphysin dimerisation and plasma membrane interaction []. Almost all members also share a conserved C-terminal Src homology 3 (SH3) domain, which mediates their interactions with the GTPase dynamin and the inositol-5'-phosphatase synaptojanin 1 in vertebrates and with actin in yeast. The central region of all these proteins is most variable. In mammals, the central region of amphiphysin I and amphiphysin IIa contains a proline-arginine-rich region for endophilin binding and a CLAP domain, for binding to clathrin and AP-2. The interactions mediated by both the central and C-terminal domains are believed to be modulated by protein phosphorylation [, ].Amphiphysins are proteins that are thought to be involved in clathrin-mediated endocytosis, actin function, and signalling pathways. In vertebrates, amphiphysins may regulate, but are not essential for clathrin-mediated endocytosis of SVs. However, in Drosophila amphiphysin is not involved at all in SV endocytosis but is required for T-tubule structure and excitation-contraction coupling muscles and plays a role in membrane morphogenesis in developing photoreceptors and a variety of other cells []. Short Name:  Amphiphysin

3 Child Features

DB identifier Type Name
IPR003017 Family Amphiphysin, isoform 1
IPR003023 Family Amphiphysin 2
IPR028827 Family Bridging integrator 2

2 Contains

DB identifier Type Name
IPR001452 Domain SH3 domain
IPR004148 Domain BAR domain

1 Cross References

Identifier
PR01251

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10559861
            9720601
            12047553