Protein Domain : IPR012048

Type:  Family Name:  Formylmethanofuran dehydrogenase, fused subunit C/D
Description:  Formylmethanofuran dehydrogenases () is found in methanogenic and sulphate-reducing archaea. The enzyme contains molybdenum or tungsten, a molybdopterin guanine dinuceotide cofactor (MGD) and iron-sulphur clusters []. It catalyses the reversible reduction of CO2and methanofuran via N-carboxymethanofuran (carbamate) to N-formylmethanofuran, the first and second steps in methanogenesis from CO2[, ]. This reaction is important for the reduction of CO2to methane, in autotrophic CO2fixation, and in CO2formation from reduced C1units []. The synthesis of formylmethanofuran is crucial for the energy metabolism of archaea. Methanogenic archaea derives the energy for autrophic growth from the reduction of CO2with molecular hydrogen as the electron donor []. The process of methanogenesis consists of a series of reduction reactions at which the one-carbon unit derived from CO2is bound to C1carriers.There are two isoenzymes of formylmethanofuran dehydrogenase: a tungsten-containing isoenzyme (Fwd) and a molybdenum-containing isoenzyme (Fmd). The tungsten isoenzyme is constitutively transcribed, whereas transcription of the molybdenum operon is induced by molybdate []. The archaea Methanobacterium thermoautotrophicumcontains a 4-subunit (FwdA, FwdB, FwdC, FwdD) tungsten formylmethanofuran dehydrogenase and a 3-subunit (FmdA, FmdB, FmdC) molybdenum formylmethanofuran dehydrogenase []. This entry represents a fusion of subunits C (FmdC) and D (FmdD) of molybdenum-containing formylmethanofuran dehydrogenase. These enzymes consist of five subunits: FmdA (), FmdB (), FmdC, FmdD and FmdE (). Short Name:  Formylmethanofuran_DH_csu/dsu
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0 Child Features

3 Contains

DB identifier Type Name
IPR002489 Domain Glutamate synthase, alpha subunit, C-terminal
IPR006657 Domain Molybdopterin dinucleotide-binding domain
IPR017550 Domain Formylmethanofuran dehydrogenase subunit C

1 Cross References

Identifier
PIRSF036633

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0018493 IPR012048
GO:0030151 IPR012048
GO:0015948 IPR012048
GO:0055114 IPR012048

4 Ontology Annotations

GO Term Gene Name
GO:0018493 IPR012048
GO:0030151 IPR012048
GO:0015948 IPR012048
GO:0055114 IPR012048

0 Parent Features

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9818358
            8575452
            8125106
            8954165
            9342247
            12492476