| Type: | Conserved_site | Name: | Glycoside hydrolase, family 6, conserved site |
| Description: | O-Glycosyl hydrolases () are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.Glycoside hydrolase family 6 comprises enzymes with several known activities; endoglucanase (); cellobiohydrolase (). These enzymes were formerly known as cellulase family B. The 3D structure of the enzymatic core of cellobiohydrolase II (CBHII) from the fungus Trichoderma reeseireveals an alpha-beta protein with a fold similar to the ubiquitous barrel topology first seen in triose phosphateisomerase []. The active site of CBHII is located at the C-terminal end ofa parallel beta barrel, in an enclosed tunnel through which the cellulose threads. Two aspartic acid residues, located in the centre of the tunnelare the probable catalytic residues []. | Short Name: | Glyco_hydro_6_CS |
