Protein Domain : IPR020590

Type:  Conserved_site Name:  Guanylate kinase, conserved site
Description:  Guanylate kinase () (GK) [] catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP. In prokaryotes (such as Escherichia coli), lower eukaryotes (such as yeast) and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown [, , ] to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus.Proteins containing one or more copies of the DHR domain, an SH3 domain as well as a C-terminal GK-like domain, are collectively termed MAGUKs (membrane-associated guanylate kinase homologues) [], andinclude Drosophila lethal(1)discs large-1 tumor suppressor protein (gene dlg1); mammalian tight junction protein Zo-1; a family of mammalian synaptic proteins that seem to interact with the cytoplasmic tail of NMDA receptor subunits (SAP90/PSD-95, CHAPSYN-110/PSD-93, SAP97/DLG1 and SAP102); vertebrate 55kDa erythrocyte membrane protein (p55); Caenorhabditis elegansprotein lin-2; rat protein CASK; and human proteins DLG2 and DLG3. There is an ATP-binding site (P-loop) in the N-terminal section of GK, which is not conserved in the GK-like domain of the above proteins. However these proteins retain the residues known, in GK, to be involved in the binding of GMP.This signature pattern covers a highly conserved region that contains two arginine and a tyrosine which are involved in GMP-binding. Short Name:  Guanylate_kinase_CS

0 Child Features

0 Contains

1 Cross References

Identifier
PS00856

4 Found Ins

DB identifier Type Name
IPR008144 Domain Guanylate kinase-like domain
IPR008145 Domain Guanylate kinase/L-type calcium channel beta subunit
IPR017665 Family Guanylate kinase
IPR016313 Family Disks large 1

0 GO Annotation

0 Ontology Annotations

0 Parent Features

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1310897
            8097461
            1314905
            8155583
            1329277