Protein Domain : IPR016331

Type:  Family Name:  Shiga-like toxin, subunit A
Description:  This entry represents subunit A of Shiga-like toxin also known as rRNA N-glycosidase; ), which are responsible for inactivation of the ribosome. Shiga-like toxins are produced by Shigella dysenteriaeand by bacteriophage that infect Escherichia colicells []. These toxins contain a single A subunit that has N-glycosidase activity and multiple copies of the B subunit that binds to the membrane glycolipid, globotriaosylceramide (Gb3). The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. It catalyses the endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA. Short Name:  Shiga-like_toxin_subunit_A
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0 Child Features

1 Contains

DB identifier Type Name
IPR017988 Conserved_site Ribosome-inactivating protein conserved site

1 Cross References

Identifier
PIRSF001924

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0030598 IPR016331
GO:0017148 IPR016331

2 Ontology Annotations

GO Term Gene Name
GO:0030598 IPR016331
GO:0017148 IPR016331

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10994531