1 Child Features
| DB identifier | Type | Name |
|---|---|---|
| IPR027262 | Family | Receptor tyrosine-protein phosphatase alpha |
| Type: | Family | Name: | Receptor tyrosine-protein phosphatase, alpha/epsilon-type |
| Description: | This entry represents receptor tyrosine-protein phosphatases (PTP) (), including both alpha type and epsilon type. PTP catalyses the dephosphorylation of protein tyrosine phosphate to protein tyrosine, and appear to play a pivotal role in insulin receptor signalling. It can exist as a single-pass membrane protein or in the cytoplasm. PTP-alpha is as a positive regulator of Src and Src family kinases, acting to dephosphorylate and activate Src. As such, PTP-alpha affects transformation and tumourigenesis, inhibition of proliferation and cell cycle arrest, mitotic activation of Src, integrin signalling, neuronal differentiation and outgrowth, and ion channel activity []. PTP-epsilon is a negative regulator of insulin signalling, where the cytosolic form has been shown to act in skeletal muscle [] and the receptor-type enzyme has been shown to act in primary hepatocytes and liver []. | Short Name: | Tyr_Pase_rcpt_a/e-type |
| DB identifier | Type | Name |
|---|---|---|
| IPR027262 | Family | Receptor tyrosine-protein phosphatase alpha |
