Protein Domain : IPR003133

Type:  Domain Name:  T antigen, Ori-binding
Description:  The group of polyomaviruses is formed by the homonymous murine virus (Py) as well as other representative members such as the simian virus 40 (SV40) and the human BK and JC viruses []. Their large T antigen (T-ag) protein binds to and activates DNA replication from the origin of DNA replication (ori). Insofar as is known, the T-ag binds to the origin first as a monomer to its pentanucleotide recognition element. The monomers are then thought to assemble into hexamers and double hexamers, which constitute the form that is active in initiation of DNA replication. When bound to the ori, T-ag double hexamers encircle DNA []. T-ag is a multidomain protein that contains an N-terminal J domain, which mediates protein interactions (see , ), a central origin-binding domain (OBD), and a C-terminal superfamily 3 helicase domain (see , ) [].This entry represents the central origin-binding domain (OBD). The overall fold of the ~130-residue T-ag OBD can be described as a central five-stranded antiparallel beta-sheet flanked by two alpha-helices on one side and one alpha-helix and one 3(10)-helix on the other. Both faces of the central beta-sheet are largely hydrophobic and are protected from solvent by the helices, thus forming two hydrophobic cores []. The T-ag OBD molecules are arranged as a spiral with a left-handed twist having six T-ag OBD's per turn. The spiral surrounds a central channel, the inner wall of which consists of alpha helices []. Short Name:  T_Ag_DNA-bd

0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF02217
PS51287

1 Found In

DB identifier Type Name
IPR016392 Family Large T antigen, polyomaviridae

2 GO Annotations

GO Term Gene Name
GO:0003688 IPR003133
GO:0006260 IPR003133

2 Ontology Annotations

GO Term Gene Name
GO:0003688 IPR003133
GO:0006260 IPR003133

0 Parent Features

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8946857
            16611889
            17139255
            8824775