3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0004325 | IPR028161 |
| GO:0043115 | IPR028161 |
| GO:0019354 | IPR028161 |
| Type: | Family | Name: | Siroheme biosynthesis protein Met8 |
| Description: | In Saccharomyces cerevisiae, Met8 is a bifunctional dehydrogenase () and ferrochelatase () []. It catalyses the final two steps in the biosynthesis of sirohaem, involving a NAD(+)-dependent dehydrogenation of precorrin-2 to generate sirohydrochlorin followed by ferrochelation to yield sirohaem []. Siroheme is a heme-like prosthetic group used by sulfite and nitrite reductases []. The structure of Met8 has been resolved. A single active site, Asp141, has been shown to play an essential role in both dehydrogenase and chelatase processes []. | Short Name: | Met8 |
| GO Term | Gene Name |
|---|---|
| GO:0004325 | IPR028161 |
| GO:0043115 | IPR028161 |
| GO:0019354 | IPR028161 |
