| Type: | Binding_site | Name: | APOBEC/CMP deaminase, zinc-binding |
| Description: | Cytidine deaminase () (cytidine aminohydrolase) catalyzes the hydrolysis of cytidine into uridine and ammonia while deoxycytidylate deaminase () (dCMP deaminase) hydrolyzes dCMP into dUMP. Both enzymes are known to bind zinc and to require it for their catalytic activity [, ]. These two enzymes do not share any sequence similarity with the exception of a region that contains three conserved histidine and cysteine residues which are thought to be involved in the binding of the catalytic zinc ion.Such a region is also found in other proteins [, ]:Yeast cytosine deaminase () (gene FCY1) which transforms cytosine into uracil.Mammalian apolipoprotein B mRNA editing protein, responsible for the postranscriptional editing of a CAA codon into a UAA (stop) codon in the APOB mRNA.Riboflavin biosynthesis protein ribG, which converts 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate.Bacillus cereusblasticidin-S deaminase (), which catalyzes the deamination of the cytosine moiety of the antibiotics blasticidin S, cytomycin and acetylblasticidin S.Bacillus subtilisprotein comEB. This protein is required for the binding and uptake of transforming DNA.B. subtilis hypothetical protein yaaJ.Escherichia colihypothetical protein yfhC.Yeast hypothetical protein YJL035c. | Short Name: | APOBEC/CMP_deaminase_Zn-bd |
