| Type: | Family | Name: | Lipocalin-1 receptor |
| Description: | Lipocalin-1 is a member of the lipocalin superfamily produced by a number of secretory glands andtissues []. The biological relevance of the many possible activities ofLcn-1 has still to be established, but its main function appears to be scavenging of lipophilic, potentially harmful molecules, providing aprotection factor for cells and tissues []. Beyond its interaction with Lcn-1, the precise physiological function of lipocalin-1 interacting membrane receptor (LIMR) is unknown. It could beinvolved in the detoxification of the ligands bound to Lcn-1, either transferring the ligand into the cell, or acting as a detoxificationprotein itself, with possible enzymatic activity similar to the membrane-associated enzymes involved in lipid molecule modification []. Currently, there is only limited data available concerning the identity of lipocalin receptors. While there is clear evidence for a specific receptorfor plasma retinol binding protein (RBP), there is only indirect evidence of receptors for alpha1-microglobulin (A1M), major urinary protein (MUP), beta-lactoglobulin, glycodelin, insecticyanin, alpha1-acid glycoprotein (AGP) and odorant binding protein (OBP). There is no consensus in themechanism of interaction between lipocalins and their receptors. Lipocalin receptors have been found to act via carbohydrate binding and protein-protein interactions. With the exception of megalin, an apparent endocyticreceptor for several soluble macromolecules including some lipocalins, no specific lipocalin receptor has so far been fully characterised.Synonym(s): Lcn-1, tear lipocalin, von Ebners gland protein | Short Name: | Lipcalin_1_rcpt |
