Protein Domain : IPR019818

Type:  Conserved_site Name:  Isocitrate/isopropylmalate dehydrogenase, conserved site
Description:  Isocitrate dehydrogenase (IDH) [, ] is an important enzyme of carbohydrate metabolism which catalyses the oxidative decarboxylation of isocitrate into alpha-ketoglutarate. IDH is either dependent on NAD+() or on NADP+(). In eukaryotes there are at least three isozymes of IDH: two are located in the mitochondrial matrix (one NAD+-dependent, the other NADP+-dependent), while the third one (also NADP+-dependent) is cytoplasmic. In Escherichia colithe activity of a NADP+-dependent form of the enzyme is controlled by the phosphorylation of a serine residue; the phosphorylated form of IDH is completely inactivated.3-isopropylmalate dehydrogenase () (IMDH) [, ] catalyses the third step in the biosynthesis of leucine in bacteria and fungi, the oxidative decarboxylation of 3-isopropylmalate into 2-oxo-4-methylvalerate. Tartrate dehydrogenase () [] catalyses the reduction of tartrate to oxaloglycolate.These enzymes are evolutionary related [, , , ]. The signature pattern of this entry is located in a conserved region, which contains a glycine-rich stretch of residues located in the C-terminal section. Short Name:  IsoCit/isopropylmalate_DH_CS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00470

8 Found Ins

DB identifier Type Name
IPR004429 Family Isopropylmalate dehydrogenase
IPR001804 Family Isocitrate and isopropylmalate dehydrogenases family
IPR004434 Family Isocitrate dehydrogenase NAD-dependent
IPR004790 Family Isocitrate dehydrogenase NADP-dependent
IPR011829 Family Tartrate dehydrogenase
IPR004439 Family Isocitrate dehydrogenase NADP-dependent, dimeric, prokaryotic
IPR014273 Family Isocitrate dehydrogenase, alphaproteobacteria-type
IPR011828 Family Isopropylmalate/isohomocitrate dehydrogenase

4 GO Annotations

GO Term Gene Name
GO:0000287 IPR019818
GO:0016616 IPR019818
GO:0051287 IPR019818
GO:0055114 IPR019818

4 Ontology Annotations

GO Term Gene Name
GO:0000287 IPR019818
GO:0016616 IPR019818
GO:0051287 IPR019818
GO:0055114 IPR019818

0 Parent Features

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8053675
            1939242
            1748999
            2682654
            7773180