Protein Domain : IPR020791

Type:  Family Name:  Leucine-tRNA ligase, archaeal
Description:  Leucine tRNA ligase () is an alpha monomer that belongs to class Ia. This entry represents a group of leucine tRNA ligases found only in Archaea.The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c. Short Name:  Leu-tRNA-lgase_arc
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0 Child Features

6 Contains

DB identifier Type Name
IPR009080 Domain Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
IPR014729 Domain Rossmann-like alpha/beta/alpha sandwich fold
IPR013155 Domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
IPR002300 Domain Aminoacyl-tRNA synthetase, class Ia
IPR009008 Domain Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
IPR001412 Conserved_site Aminoacyl-tRNA synthetase, class I, conserved site

1 Cross References

Identifier
MF_00049_A

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0000166 IPR020791
GO:0004823 IPR020791
GO:0005524 IPR020791
GO:0006429 IPR020791
GO:0005737 IPR020791

5 Ontology Annotations

GO Term Gene Name
GO:0000166 IPR020791
GO:0004823 IPR020791
GO:0005524 IPR020791
GO:0006429 IPR020791
GO:0005737 IPR020791

1 Parent Features

DB identifier Type Name
IPR004493 Family Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8364025
            8274143
            1852601
            2053131
            10673435
            2203971