Protein Domain : IPR020557

Type:  Conserved_site Name:  Fumarate lyase, conserved site
Description:  A number of enzymes, belonging to the lyase class, for which fumarate is a substrate, have been shown to share a short conserved sequence around a methionine which is probably involved in the catalytic activity of this typeof enzymes []. The following are examples of members of this family:: 3-carboxymuconate lactonizing enzyme, (3-carboxy-cis,cis-muconate cycloisomerase), an enzyme involved in aromatic acids catabolism []. : Delta-crystallin shares around 90% sequence identity with arginosuccinate lyase, showing that it is an example of a 'hijacked' enzyme - accumulated mutations have, however, rendered the protein enzymatically inactive.: Class I Fumarase enzyme, (fumarate hydratase), which catalyses the reversible hydration of fumarate to L-malate. Class I enzymes are thermolabile dimeric enzymes (as for example: Escherichia colifumC).: Arginosuccinase, (argininosuccinate lyase), which catalyses the formation of arginine and fumarate from argininosuccinate, the last step in the biosynthesis of arginine. : Aspartate ammonia-lyase, (aspartase), which catalyses the reversible conversion of aspartate to fumarate and ammonia. This reaction is analogous to that catalyzed by fumarase, except that ammonia rather than water is involved in the trans-elimination reaction. : class II Fumarase enzyme, , are thermostable and tetrameric and are found in prokaryotes (as for example: E. coli fumA and fumB) as well as in eukaryotes. The sequence of the two classes of fumarases are not closely related.: Adenylosuccinase, (adenylosuccinate lyase) [], which catalyses the eighth step in the de novo biosynthesis of purines, the formation of 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide and fumarate from 1-(5-phosphoribosyl)-4-(N-succino-carboxamide). That enzyme can also catalyse the formation of fumarate and AMP from adenylosuccinate. This signature contains the conserved methionine which is probably involved in the catalytic activity. Short Name:  Fumarate_lyase_CS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00163

10 Found Ins

DB identifier Type Name
IPR004769 Family Adenylosuccinate lyase
IPR005677 Family Fumarate hydratase, class II
IPR022761 Domain Fumarate lyase, N-terminal
IPR009049 Family Argininosuccinate lyase
IPR008948 Domain L-Aspartase-like
IPR000362 Family Fumarate lyase family
IPR011167 Family Iron-dependent fumarate hydratase
IPR004708 Family Aspartate ammonia-lyase
IPR012789 Family 3-carboxy-cis,cis-muconate cycloisomerase
IPR011244 Family Bifunctional argininosuccinate lyase/acetyltransferase

1 GO Annotation

GO Term Gene Name
GO:0003824 IPR020557

1 Ontology Annotations

GO Term Gene Name
GO:0003824 IPR020557

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1390752
            3282546
            1574589