3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0003677 | IPR015558 |
| GO:0003700 | IPR015558 |
| GO:0006355 | IPR015558 |
| Type: | Family | Name: | Transcription Factor c-Jun/v-Jun |
| Description: | Transcription factor c-Jun is a member of the transcription factor activator protein (AP)-1 family, comprising Jun (c-Jun, JunB, and JunD), Fos (c-Fos, FosB, Fra1, and Fra2), ATF (ATFa, ATF-2 and ATF-3) and JDP (JDP-1 and JDP-2) family members []. They are basic leucine zipper transcription factors that play a central role in regulating gene transcription in various biological processes []. c-Jun was originally identified as the normal cellular counterpart of the viral Jun oncoprotein (v-Jun) encoded by an avian sarcoma virus (ASV17). The 39kDa c-Jun protein consists of a C-terminal basic region-leucine zipper (B-ZIP) DNA-binding domain and a N-terminal transcriptional activation domain.AP-1 proteins have a alpha-helical bZIP domain, which contains a basic DNA-binding region and regularly spaced leucine residues known as the leucine zipper motif []. They have similar protein structure and can either form homodimers or form heterodimers with other AP-1 proteins (predominantly with Jun proteins), which can then bind to TRE-like sequences (consensus sequence 5'-TGAG/CTCA-3') []. Each of these proteins are expressed in different tissues and can be regulated in different ways, which means that every cell type has a complex mixture of AP-1 dimers with subtly different functions []. | Short Name: | C_Jun/v-Jun |
| GO Term | Gene Name |
|---|---|
| GO:0003677 | IPR015558 |
| GO:0003700 | IPR015558 |
| GO:0006355 | IPR015558 |
