| Type: | Family | Name: | p53 tumour suppressor family |
| Description: | The p53 tumour suppressor [, , , , ] is a protein found in increased amounts in a wide variety of transformed cells. It is also detectable in many proliferating non-transformed cells, but it is undetectable or present at low levels in resting cells. It is frequently mutated or inactivated in many types of cancer. p53 seems to act as a tumour suppressor in some, but probably not all, tumour types. p53 has been implicated in cell cycle regulation, particularly in the monitoring of genomic DNA integrity prior to replication; for this reason it has been dubbed `guardian of the genome'. p53 is a sequence-specific DNA-binding protein and transcription factor. The structure of p53 comprises 4 domains: an N-terminal transactivation domain; a central DNA-binding domain; an oligomerisation domain; and a C-terminal, basic, regulatory domain [, ]. The structure of the oligomerisation domain consists of a dimer of dimers, each dimer consisting of 2 anti-parallel alpha-helices and an anti-parallel beta-sheet. The sheets lie on opposite sides of the tetramer and the helices form an unusual 4-helix bundle [, ]. While the majority of p53 mutations found in human cancers are located in the DNA-binding domain, some are also found in the oligomerisation domain.This entry also includes the p53 family members p63 [], p73 [] and transcription factor cep-1 []. | Short Name: | p53_tumour_suppressor |
| GO Term | Gene Name |
|---|---|
| GO:0003677 | IPR002117 |
| GO:0003700 | IPR002117 |
| GO:0006355 | IPR002117 |
| GO:0006915 | IPR002117 |
| GO:0005634 | IPR002117 |
| GO Term | Gene Name |
|---|---|
| GO:0003677 | IPR002117 |
| GO:0003700 | IPR002117 |
| GO:0006355 | IPR002117 |
| GO:0006915 | IPR002117 |
| GO:0005634 | IPR002117 |
