3 Ontology Annotations
GO Term | Gene Name |
---|---|
GO:0008028 | IPR004743 |
GO:0015718 | IPR004743 |
GO:0016021 | IPR004743 |
Type: | Family | Name: | Monocarboxylate transporter |
Description: | Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [, ]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7. Four mammalian isoforms, MCTs 1-4, have been identified, each with distinct substrate and inhibitor affinities []. MCT1-4 have been linked to cancer maintenance and aggressiveness []. | Short Name: | MCT |
GO Term | Gene Name |
---|---|
GO:0008028 | IPR004743 |
GO:0015718 | IPR004743 |
GO:0016021 | IPR004743 |