Protein Domain : IPR017983

Type:  Conserved_site Name:  GPCR, family 2, secretin-like, conserved site
Description:  G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The secretin-like GPCRs include secretin [], calcitonin [], parathyroid hormone/parathyroid hormone-related peptides [] and vasoactive intestinal peptide [], all of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. These receptors contain seven transmembrane regions, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins (however there is no significant sequence identity between these families, the secretin-like receptors thus bear their own unique '7TM' signature). Their N terminus is probably located on the extracellular side of the membrane and potentially glycosylated. This N-terminal region contains a long conserved region which allow the binding of large peptidic ligand such as glucagon, secretin, VIP and PACAP; this region contains five conserved cysteines residues which could be involved in disulphide bond. The C-terminal region of these receptor is probably cytoplasmic. Every receptor gene in this family is encoded on multiple exons, and several of these genes are alternatively spliced to yield functionally distinct products. This entry represents a pair of conserved sites found within family 2 GPCR receptor proteins. The first conserved site spans three of the five highly conserved cysteine residues found within the N-terminal extracellular domain that may be involved in disulphide bonds. The second conserved site within a region spanning the C-terminal part of the last transmembrane region and the beginning of the adjacent intracellular region. Short Name:  GPCR_2_secretin-like_CS
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PS00649
PS00650

21 Found Ins

DB identifier Type Name
IPR000832 Family GPCR, family 2, secretin-like
IPR001879 Domain GPCR, family 2, extracellular hormone receptor domain
IPR002144 Family GPCR, family 2, secretin receptor
IPR002170 Family GPCR, family 2, parathyroid hormone receptor
IPR002001 Family GPCR, family 2, diuretic hormone receptor
IPR002284 Family GPCR, family 2, vasoactive intestinal peptide receptor 2
IPR001571 Family GPCR, family 2, vasoactive intestinal peptide receptor
IPR002285 Family GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor
IPR003924 Family GPCR, family 2, latrophilin
IPR001749 Family GPCR, family 2, gastric inhibitory polypeptide receptor
IPR003051 Family GPCR, family 2, corticotropin releasing factor receptor
IPR003287 Family GPCR, family 2, calcitonin receptor family
IPR003052 Family GPCR, family 2, corticotropin releasing factor receptor, type 1
IPR003053 Family GPCR, family 2, corticotropin releasing factor receptor, type 2
IPR001688 Family GPCR, family 2, calcitonin receptor
IPR003289 Family GPCR, family 2, calcitonin gene-related peptide, type 1 receptor
IPR003288 Family GPCR, family 2, growth hormone-releasing hormone receptor
IPR003290 Family GPCR, family 2, glucagon-like peptide-1/glucagon receptor
IPR003291 Family GPCR, family 2, glucagon receptor
IPR003292 Family GPCR, family 2, glucagon-like peptide-1 receptor
IPR001771 Family GPCR, family 2, vasoactive intestinal peptide receptor 1

3 GO Annotations

GO Term Gene Name
GO:0004930 IPR017983
GO:0007186 IPR017983
GO:0016020 IPR017983

3 Ontology Annotations

GO Term Gene Name
GO:0004930 IPR017983
GO:0007186 IPR017983
GO:0016020 IPR017983

0 Parent Features

0 Proteins

11 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8170923
            16753280
            23020293
            12679517
            8081729
            15914470
            18948278
            1646711
            1314625
            1658940
            1658941