3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0003677 | IPR028612 |
| GO:0003916 | IPR028612 |
| GO:0006265 | IPR028612 |
| Type: | Family | Name: | DNA topoisomerase I, type IA |
| Description: | DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single- or double-strand breaks, crossing the strands through one another, then resealing the breaks []. These enzymes have several functions: to remove DNA supercoils during transcription and DNA replication; for strand breakage during recombination; for chromosome condensation; and to disentangle intertwined DNA during mitosis [, ]. DNA topoisomerases are divided into two classes: type I enzymes (; topoisomerases I, III and V) break single-strand DNA, and type II enzymes (; topoisomerases II, IV and VI) break double-strand DNA [].Type I topoisomerases are ATP-independent enzymes (except for reverse gyrase), and can be subdivided according to their structure and reaction mechanisms: type IA (bacterial and archaeal topoisomerase I, topoisomerase III and reverse gyrase) and type IB (eukaryotic topoisomerase I and topoisomerase V). These enzymes are primarily responsible for relaxing positively and/or negatively supercoiled DNA, except for reverse gyrase, which can introduce positive supercoils into DNA. This entry describes archaeal and bacterial-type topoisomerase I, which belongs to type 1A topoisomerases []. | Short Name: | Topoisom_1_IA |
| GO Term | Gene Name |
|---|---|
| GO:0003677 | IPR028612 |
| GO:0003916 | IPR028612 |
| GO:0006265 | IPR028612 |
