Protein Domain : IPR028646

Type:  Family Name:  Sorting nexin-18
Description:  Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding proteins that have roles in cargo sorting through the endosomal netwrok []. Sorting nexins contain at least a PX domain (a phospholipid-binding motif). Some nexins contain a few additional domains. Proteins in the sorting nexin 9 subfamily includes SNX9, SNX18 and SNX33 []. They are characterised by the presence of an N-terminal SH3 domain (), a PX domain that is a phosphoinositide-binding module (), and a Bin/Amphiphysin/Rvs (BAR) domain at the C terminus, which allows membrane binding and bending. They are required for progression and completion of mitosis []. This entry represents SNX18, which acts as a membrane tubulator in AP (adaptor proteins)-1-positive endosomal trafficking []. It has a similar role to SNX9 in endocytic trafficking at the plasma membrane []. Short Name:  SNX18
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10555:SF13

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0035091 IPR028646
GO:0000281 IPR028646
GO:0006886 IPR028646
GO:0006897 IPR028646

4 Ontology Annotations

GO Term Gene Name
GO:0035091 IPR028646
GO:0000281 IPR028646
GO:0006886 IPR028646
GO:0006897 IPR028646

1 Parent Features

DB identifier Type Name
IPR014536 Family Sorting nexin 9 subfamily

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            22718350
            22193161
            18411244
            20427313