3 Ontology Annotations
GO Term | Gene Name |
---|---|
GO:0007155 | IPR012011 |
GO:0007596 | IPR012011 |
GO:0005578 | IPR012011 |
Type: | Family | Name: | von Willebrand factor |
Description: | von Willebrand factor (vWF) is a multimeric adhesive protein that plays a key role in platelet function by mediating the initiation and progression of thrombus formation at sites of vascular injury []. Binding of vWF to platelet membrane glycoprotein GPIb-alpha () of the GPIb-IX-V complex supports the arrest of bleeding after tissue trauma. The rapid association of GP1b-alpha with vWF not only initiates platelet deposition at the sites of vascular injury but is essential for maintaining thrombus growth in blood flowing at high shear rates. | Short Name: | VWF |
GO Term | Gene Name |
---|---|
GO:0007155 | IPR012011 |
GO:0007596 | IPR012011 |
GO:0005578 | IPR012011 |