Protein Domain : IPR028644

Type:  Family Name:  Sorting nexin-9
Description:  Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding proteins that have roles in cargo sorting through the endosomal netwrok []. Sorting nexins contain at least a PX domain (a phospholipid-binding motif). Some nexins contain a few additional domains. Proteins in the sorting nexin 9 subfamily includes SNX9, SNX18 and SNX33 []. They are characterised by the presence of an N-terminal SH3 domain (), a PX domain that is a phosphoinositide-binding module (), and a Bin/Amphiphysin/Rvs (BAR) domain at the C terminus, which allows membrane binding and bending. They are required for progression and completion of mitosis []. Sorting nexin 9 (SNX9) is a well-characterised member of this group; it is has been suggested to be involved in the endocytic process as an accessory factor []. SNX9 has binding sites for both clathrin and adaptor protein AP-2 in a low complexity region, and binds dynamin-2 (Dyn2) by its SH3 domain. SNX9 has its own membrane-binding activity, mediated by a carboxyl-terminal region containing the PX domain and the BAR domain []. Endogenous SNX9 partially co-localizes with AP-2 and Dyn2 at the plasma membrane, and over expression in K562 and HeLa cells of truncated versions of SNX9 inhibits the uptake of transferrin []. Moreover, SNX9 is required for efficient clathrin-mediated endocytosis, which suggests that it functions to regulate dynamin activity []. Short Name:  SNX9
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10555:SF14

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0035091 IPR028644
GO:0000281 IPR028644
GO:0006886 IPR028644
GO:0006897 IPR028644

4 Ontology Annotations

GO Term Gene Name
GO:0035091 IPR028644
GO:0000281 IPR028644
GO:0006886 IPR028644
GO:0006897 IPR028644

1 Parent Features

DB identifier Type Name
IPR014536 Family Sorting nexin 9 subfamily

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            22718350
            15703209
            22193161
            12952949
            11879186