Protein Domain : IPR028623

Type:  Family Name:  HNS-dependent expression B
Description:  HNS (histone-like nucleoid structuring)-dependent expression A (HdeA) protein is a stress response protein found in highly acid resistant bacteria such as Shigella flexneriand Escherichia coli, but which is lacking in mildly acid tolerant bacteria such as Salmonella []. HdeA is one of the most abundant proteins found in the periplasmic space of E. coli, where it is one of a network of proteins that confer an acid resistance phenotype essential for the pathogenesis of enteric bacteria []. HdeA is thought to act as a chaperone, functioning to prevent the aggregation of periplasmic proteins denatured under acidic conditions. The HNS protein, a chromatin-associated protein that influences the gene expression of several environmentally-induced target genes, represses the expression of HdeA. HdeB, which is encoded within the same operon, may form heterodimers with HdeA. HdeA is a single domain alpha-helical [] protein with an overall fold that is similar to the fold of the N-terminal subdomain of the GluRS anticodon-binding domain. This entry represents acid stress chaperone HdeB []. Short Name:  HdeB

0 Child Features

0 Contains

1 Cross References

Identifier
MF_00947

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0051082 IPR028623
GO:0009268 IPR028623

2 Ontology Annotations

GO Term Gene Name
GO:0051082 IPR028623
GO:0009268 IPR028623

1 Parent Features

DB identifier Type Name
IPR010486 Family HNS-dependent expression A/B

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12694615
            10623550
            17085547