| Type: | Conserved_site | Name: | NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site |
| Description: | NADH:ubiquinone oxidoreductase (complex I) () is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) []. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins []. This entry represents a highly conserved region found towards the N terminus of the 49 kDa subunit of NADH:ubiquinone oxidoreductase. | Short Name: | NADH_UbQ_OxRdtase_49kDa_CS |
