Protein Domain : IPR000838

Type:  Conserved_site Name:  RNA polymerase sigma factor 70, ECF, conserved site
Description:  The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with the core RNA polymerase complex to form a holoenzyme []. RNA polymerase recruits alternative sigma factors as a means of switching on specific regulons. Most bacteria express a multiplicity of sigma factors. Two of these factors, sigma-70 (gene rpoD), generally known as the major or primary sigma factor, and sigma-54 (gene rpoN or ntrA) direct the transcription of a wide variety of genes. The other sigma factors, known as alternative sigma factors, are required for the transcription of specific subsets of genes.With regard to sequence similarity, sigma factors can be grouped into two classes, the sigma-54 and sigma-70 families. Sequence alignments of the sigma70 family members reveal four conserved regions that can be further divided into subregions eg. sub-region 2.2, which may be involved in the binding of the sigma factor to the core RNA polymerase; and sub-region 4.2, which seems to harbor a DNA-binding 'helix-turn-helix' motif involved in binding the conserved -35 region of promoters recognised by the major sigma factors [, ]. The proteins in this entry are currently known to belong to this sigma factor subfamily, known as ECF; these include Pseudomonas aeruginosaalgU; Myxococcus xanthuscarQ; Ralstonia eutropha(Alcaligenes eutrophus) plasmid pMOL28-encoded cnrH; Escherichia colifecI; Pseudomonas syringaehrpL; rpoE from E. coli, Salmonella typhimuriumand Haemophilus influenzae; Streptomyces coelicolorsigE; and Bacillus subtilissigma factors sigV, sigX, sigY and sigZ. Short Name:  RNA_pol_sigma70_ECF_CS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS01063

7 Found Ins

DB identifier Type Name
IPR014284 Domain RNA polymerase sigma-70 like domain
IPR013325 Domain RNA polymerase sigma factor, region 2
IPR007627 Domain RNA polymerase sigma-70 region 2
IPR014305 Family RNA polymerase sigma-G type, actinobacteria
IPR014286 Family RNA polymerase sigma-70 RpoE type
IPR014293 Family RNA polymerase sigma-70, actinobacteria
IPR014294 Family RNA polymerase sigma-W, bacillaceae

5 GO Annotations

GO Term Gene Name
GO:0003677 IPR000838
GO:0003700 IPR000838
GO:0016987 IPR000838
GO:0006352 IPR000838
GO:0006355 IPR000838

5 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR000838
GO:0003700 IPR000838
GO:0016987 IPR000838
GO:0006352 IPR000838
GO:0006355 IPR000838

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3052291
            1597408
            3092189