Protein Domain : IPR018000

Type:  Conserved_site Name:  Neurotransmitter-gated ion-channel, conserved site
Description:  Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [, ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily:Nicotinic acetylcholine receptor (AchR), an excitatory cation channel in vertebrates and invertebrates; in vertebrate motor endplates it is composed of alpha, beta, gamma and delta/epsilon subunits; in neurons it is composed of alpha and non-alpha (or beta) subunits [].Glycine receptor, an inhibitory chloride ion channel composed of alpha and beta subunits [].Gamma-aminobutyric acid (GABA) receptor, an inhibitory chloride ion channel; at least four types of subunits (alpha, beta, gamma and delta) are known [].Serotonin 5HT3 receptor, of which there are seven major types (5HT3-5HT7) [].Glutamate receptor, an excitatory cation channel of which at least three types have been described (kainate, N-methyl-D-aspartate (NMDA) and quisqualate) [].These receptors possess a pentameric structure (made up of varying subunits), surrounding a central pore. All known sequences of subunits from neurotransmitter-gated ion-channels are structurally related. They are composed of a large extracellular glycosylated N-terminal ligand-binding domain, followed by three hydrophobic transmembrane regions which form the ionic channel, followed by an intracellular region of variable length. A fourth hydrophobic region is found at the C-terminal of the sequence [, ].This entry represents a conserved site based around two highly conserved cysteines in the N-terminal of AchR/GABA/5HT3/Gly receptors. The residues between these two cysteines are also well conserved. In AchR, these cysteine residues have been shown to form a disulphide bond essential to the tertiary structure of the receptor. Short Name:  Neurotransmitter_ion_chnl_CS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00236

28 Found Ins

DB identifier Type Name
IPR006202 Domain Neurotransmitter-gated ion-channel ligand-binding domain
IPR006201 Family Neurotransmitter-gated ion-channel
IPR002394 Family Nicotinic acetylcholine receptor
IPR002289 Family Gamma-aminobutyric-acid A receptor, beta subunit
IPR005437 Family Gamma-aminobutyric-acid A receptor, gamma subunit
IPR005438 Family Gamma-aminobutyric-acid A receptor, gamma 1 subunit
IPR005439 Family Gamma-aminobutyric-acid A receptor, gamma 2 subunit
IPR005440 Family Gamma-aminobutyric-acid A receptor, gamma 3 subunit
IPR005435 Family Gamma-aminobutyric-acid A receptor, alpha 5 subunit
IPR001390 Family Gamma-aminobutyric-acid A receptor, alpha subunit
IPR005436 Family Gamma-aminobutyric-acid A receptor, alpha 6 subunit
IPR005433 Family Gamma-aminobutyric-acid A receptor, alpha 3 subunit
IPR005431 Family Gamma-aminobutyric-acid A receptor, alpha 1 subunit
IPR005432 Family Gamma-aminobutyric-acid A receptor, alpha 2 subunit
IPR015680 Family Glutamate-Gated Chloride Channel
IPR008059 Family Gamma-aminobutyric-acid A receptor, Rho2
IPR008057 Family Gamma-aminobutyric-acid A receptor, Rho
IPR008058 Family Gamma-aminobutyric-acid A receptor, Rho1
IPR008060 Family Glycine receptor beta
IPR008098 Family Gamma-aminobutyric-acid A receptor delta subunit
IPR008129 Family Glycine receptor alpha2
IPR008127 Family Glycine receptor alpha
IPR008128 Family Glycine receptor alpha1
IPR008130 Family Glycine receptor alpha3
IPR008132 Family 5-hydroxytryptamine 3 receptor
IPR008133 Family 5-hydroxytryptamine 3 receptor, A subunit
IPR008101 Family Gamma-aminobutyric-acid A receptor theta subunit
IPR008100 Family Gamma-aminobutyric-acid A receptor pi subunit

0 GO Annotation

0 Ontology Annotations

0 Parent Features

0 Proteins

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1721053
            1846404
            10026168
            18446614
            15383648
            18760291
            15165736