| Type: | Family | Name: | Muscarinic acetylcholine receptor M1 |
| Description: | Muscarinic acetylcholine receptors are members of rhodopsin-like G-protein coupled receptor family. They play several important roles; they mediate many of the effects of acetylcholine in the central and peripheral nervous system and modulate a variety of physiological functions, such as airway, eye and intestinal smooth muscle contraction, heart rate and glandular secretions. The receptors have a widespread tissue distribution and are a major drug target in human disease. They may be effective therapeutic targets in Alzheimer's disease, schizophrenia, Parkinson's disease and chronic obstructive pulmonary disease [, ]. There are five muscarinic acetylcholine receptor subtypes, designated M1-5 [, , , , ]. The family can be further divided into two broad groups based on their primary coupling to G-proteins. M2 and M4 receptors couple to the pertussis-toxin sensitive Gi proteins, whereas M1, M3 and M5 receptors couple to Gq proteins [, ], which activate phospholipase C. The different subtypes can also couple to a wide range of diverse signalling pathways, some of which are G protein-independent [, , ].All subtypes seem to serve as autoreceptors [], and knockout mice reveal the important neuromodulatory role played by this receptor family [, , ].Muscarinic acetylcholine receptor M1 it is common in exocrine glands and the CNS [, , ], being is particularly abundant in the cerebal cortex and hippocampus [, ]. The receptors have also been also found on esophageal smooth muscle [] and bladder tissue []. Their distribution largely overlaps with that of M3 and M4 receptors. M1 receptors are involved in mediating higher cognitive processes, such as learning and memory []. They also play a role in regulation of locomotor activity [] and in salivation []. | Short Name: | Musac_Ach_M1_rcpt |
| GO Term | Gene Name |
|---|---|
| GO:0016907 | IPR002228 |
| GO:0007186 | IPR002228 |
| GO:0040012 | IPR002228 |
| GO:0046541 | IPR002228 |
| GO:0050890 | IPR002228 |
| GO:0005887 | IPR002228 |
| GO Term | Gene Name |
|---|---|
| GO:0016907 | IPR002228 |
| GO:0007186 | IPR002228 |
| GO:0040012 | IPR002228 |
| GO:0046541 | IPR002228 |
| GO:0050890 | IPR002228 |
| GO:0005887 | IPR002228 |
