3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0004792 | IPR028885 |
| GO:0002143 | IPR028885 |
| GO:0005829 | IPR028885 |
| Type: | Family | Name: | Adenylyltransferase and sulfurtransferase MOCS3/Uba4 |
| Description: | This entry includes adenylyltransferase and sulfurtransferase MOCS3 and its homologue, Uba4, from yeasts.In budding yeasts, Uba4 receives sulphur from Nfs1 and Tum1 []. Uba4 then forms an acyl adenylate intermediate with the C-terminal of the Urm1 protein, and then forms an acyl disulfide bond between Uba4 Cys397 and the Urm1 C-terminal glycin []. Subsequently, the activated Urm1 acts as a sulphur carrier in the process of eukaryotic transfer RNA (tRNA) thiolation []. MOCS3 plays a central role in 2-thiolation of mcm5S2U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) []. It is also essential during biosynthesis of the molybdenum cofactor [, ]. MOCS3 acts by mediating the C-terminal thiocarboxylation of sulfur carriers Urm1 and MOCS2A (the small subunit of molybdopterin synthase) [, , , ]. | Short Name: | MOCS3/Uba4 |
| GO Term | Gene Name |
|---|---|
| GO:0004792 | IPR028885 |
| GO:0002143 | IPR028885 |
| GO:0005829 | IPR028885 |
