Protein Domain : IPR026217

Type:  Family Name:  Ddc1
Description:  This entry represents the budding yeast Ddc1, which is homologous to the fission yeast and human Rad9. DNA-damage checkpoint protein 1 (Ddc1) forms a checkpoint clamp complex with Mec3 and Rad17 [, ]. This complex plays a role in the surveillance system that permits DNA-repair pathways to restore the integrity of DNA in advance of DNA synthesis or separation of replicated chromosomes, thereby ensuring that new phases are not entered if DNA is damaged []. Ddc1 can activate Mec1 (the principal checkpoint protein kinase, human ATR homologue) in G1 phase. In G2 phase, Ddc1 can either activate Mec1 directly or recruit Dpb11 (ortholog of human TopBP1) and subsequently activate Mec1 []. Ddc1 does not have the DNA exonuclease function []. Short Name:  Ddc1
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0 Child Features

0 Contains

1 Cross References

Identifier
PR02063

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0000075 IPR026217
GO:0000725 IPR026217
GO:0007126 IPR026217
GO:0031573 IPR026217
GO:0000794 IPR026217
GO:0030896 IPR026217

6 Ontology Annotations

GO Term Gene Name
GO:0000075 IPR026217
GO:0000725 IPR026217
GO:0007126 IPR026217
GO:0031573 IPR026217
GO:0000794 IPR026217
GO:0030896 IPR026217

1 Parent Features

DB identifier Type Name
IPR007268 Family Rad9/Ddc1

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9311982
            12604797
            9891048
            20005839