1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR012143 | Family | Dimethylaniline monooxygenase, N-oxide-forming |
| Type: | Family | Name: | Flavin monooxygenase (FMO) 4 |
| Description: | Flavin-containing monooxygenases (FMOs) constitute a family of xenobiotic- metabolising enzymes []. Using an NADPH cofactor and FAD prosthetic group,these microsomal proteins catalyse the oxygenation of nucleophilic nitrogen, sulphur, phosphorous and selenium atoms in a range of structurally diversecompounds. Five mammalian forms of FMO are now known and have been designated FMO1-FMO5 [, , , , ].FMO4 mRNA is present in low abundance in several foetal and adult tissues and the corresponding gene thus appears to be expressed constitutively [].Sequence analysis reveals that FMO4 is 56% identical to FMO3; each is encoded by a single gene []. The deduced amino acid sequence of human FM04 includes the putative FAD- (GxGxxG) and NADP+pyrophosphate-binding (GxGxxA) sites characteristic of mammalian FMOs, a 'FATGY' motif that has also beenobserved in a range of siderphore biosynthetic enzymes [], and a C-terminalhydrophobic segment that is believed to anchor the monooxygenase to the microsomal membrane []. | Short Name: | Flavin_mOase_4 |
| DB identifier | Type | Name |
|---|---|---|
| IPR012143 | Family | Dimethylaniline monooxygenase, N-oxide-forming |
