| Type: | Family | Name: | Cyclin-O |
| Description: | Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles, and regulate cyclin dependent kinases (CDKs) [].This entry represents cyclin-O. In mouse oocytes, it regulates maturation-promoting factor (MPF), which affects oocyte meiotic resumption []. It is required to activate Cdk2 during apoptosis induced by intrinsic stimuli in lymphoid cells []. Its activity is modulated by p53 and members of the Bcl-2 protein family []. This entry also includes cyclin-O protein A/B, also known as CCNO, from Xenopus laevis. Mutations in CCNO result in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia []. | Short Name: | Ccno |
