3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0004930 | IPR002280 |
| GO:0007186 | IPR002280 |
| GO:0016021 | IPR002280 |
| Type: | Family | Name: | Melatonin-related receptor 1X |
| Description: | Melatonin is a naturally occurring compound found in animals, plants, and microbes [, ]. In animals melatonin is secreted by the pineal gland during darkness [, ]. It regulates a variety of neuroendocrine functions and is thought to play an essential role in circadian rhythms []. Drugs that modify the action of melatonin, and hence influence circadian cycles, are of clinical interest for example, in the treatment of jet-lag []. Many of the biological effects of melatonin are produced through the activation of melatonin receptors [], which are members of rhodopsin-like G protein-coupled receptor family. There are three melatonin receptor subtypes. Melatonin receptor type 1A and melatonin receptor type 1B are present in humans and other mammals [] while melatonin receptor type 1C has been identified in amphibia and birds []. There is also a closely-related orphan receptor, termed melatonin-related receptor type 1X (also known as GPR50) [], is yet to achieve receptor status from the International Union of Basic and Clinical Pharmacology (IUPHAR), since a robust response mediated via the protein has not been reported in the literature. Melatonin receptor type 1C receptors are 80% identical and are distinct from 1A and 1B subtypes. Similar ligand binding and functional characteristics are observed in expressed 1A and 1C receptors. The melatonin receptors inhibit adenylyl cyclase via a pertussis-toxin-sensitive G-protein, probably of the Gi/Go class. This entry represents melatonin-related receptor 1X from human pituitary, also known as G protein-coupled receptor 50 (GPR50). It is the mammalian orthologue of melatonin receptor 1C described in non-mammalian vertebrates []. It is closely related to the other melatonin subtypes as it is 45% identical to human 1A and 1B receptors [], However, it lacks N-linked glycosylation sites and bears a >300 residue C-terminal tail. 1X receptor is expressed in hypothalamus and pituitary, suggesting that the receptor and its natural ligand are involved in neuroendocrine function []. | Short Name: | Mel_rcpt_1X |
| GO Term | Gene Name |
|---|---|
| GO:0004930 | IPR002280 |
| GO:0007186 | IPR002280 |
| GO:0016021 | IPR002280 |
