Protein Domain : IPR030168

Type:  Family Name:  NAD(P) transhydrogenase, mitochondrial
Description:  Mitochondrial energy-transducing H+ translocating transhydrogenase, also known as nicotinamide nucleotide transhydrogenase (NNT), is found in the mitochondrion inner membrane. It catalyses hydride transfer between NAD(H) and NADP(+) coupled to proton translocation across the inner membrane. It is composed of 3 domains: an N-terminal domain which binds NAD(H), a C-terminal domain which binds NADP(H), and a hydrophobic central domain made up mainly of about 14 hydrophobic clusters of approximately 20 residues each [, ]. NNT has a role in mitochondrial redox regulation [] and is a regulator of macrophage-mediated inflammatory responses []. Short Name:  NADP_transhyd_mt
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10160:SF22

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0008746 IPR030168
GO:0015992 IPR030168
GO:0045454 IPR030168
GO:0055114 IPR030168
GO:0005743 IPR030168

5 Ontology Annotations

GO Term Gene Name
GO:0008746 IPR030168
GO:0015992 IPR030168
GO:0045454 IPR030168
GO:0055114 IPR030168
GO:0005743 IPR030168

1 Parent Features

DB identifier Type Name
IPR026255 Family NAD(P) transhydrogenase, alpha subunit

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2005110
            3277960
            24722990
            22593545