Protein Domain : IPR000239

Type:  Family Name:  GPCR kinase
Description:  Rapid regulation of G-protein-coupled receptors (GPCRs) involves agonist-promoted receptor phosphorylation by GPCR kinases (GRKs) []. This processis followed by arrestin binding and transient receptor internalisation. It has been shown that beta-adrenergic receptor kinase (beta ARK-1 or GRK2)follows a similar pattern of internalisation upon agonist activation of beta(2)-adrenergic receptors (beta(2)AR) and that beta ARK expressionlevels modulate receptor sequestration []. Such studies indicate afunctional relationship between receptor phosphorylation and sequestration, showing that beta ARK not only translocates from the cytoplasm to theplasma membrane in response to receptor occupancy, but also shares endocytic mechanisms with the beta(2)AR []. These results suggest a rolefor beta ARK in the sequestration process, or involvement of receptor internalisation in the intracellular trafficking of the kinase []. Short Name:  GPCR_kinase
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0 Child Features

6 Contains

DB identifier Type Name
IPR000719 Domain Protein kinase domain
IPR011009 Domain Protein kinase-like domain
IPR002290 Domain Serine/threonine/dual specificity protein kinase, catalytic domain
IPR000961 Domain AGC-kinase, C-terminal
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008271 Active_site Serine/threonine-protein kinase, active site

1 Cross References

Identifier
PR00717

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004703 IPR000239
GO:0005524 IPR000239
GO:0006468 IPR000239
GO:0007165 IPR000239

4 Ontology Annotations

GO Term Gene Name
GO:0004703 IPR000239
GO:0005524 IPR000239
GO:0006468 IPR000239
GO:0007165 IPR000239

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9092483