Protein Domain : IPR002729

Type:  Family Name:  CRISPR-associated protein Cas1
Description:  The CRISPR-Cas system is a prokaryotic defense mechanism against foreign genetic elements. The key elements of this defense system are the Cas proteins and the CRISPR RNA. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) are a family of DNA direct repeats separated by regularly sized non-repetitive spacer sequences that are found in most bacterial and archaeal genomes []. CRISPRs appear to provide acquired resistance against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).The defense reaction is divided into three stages. In the adaptation stage, the invader DNA is cleaved, and a piece of it is selected to be integrated as a new spacer into the CRISPR locus, where it is stored as an identity tag for future attacks by this invader. During the second stage (the expression stage), the CRISPR RNA (pre-crRNA) is transcribed and subsequently processed into the mature crRNAs. In the third stage (the interference stage), Cas proteins, together with crRNAs, identify and degrade the invader [, , ].The CRISPR-Cas systems have been sorted into three major classes. In CRISPR-Cas types I and III, the mature crRNA is generally generated by a member of the Cas6 protein family. Whereas in system III the Cas6 protein acts alone, in some class I systems it is part of a complex of Cas proteins known as Cascade (CRISPR-associated complex for antiviral defense). The Cas6 protein is necessary for crRNA production whereas the additional Cas proteins that form the Cascade complex are needed for crRNA stability []. This entry represents Cas1, which is a metal-dependent DNA-specific endonuclease []. Cas1 may play a role in the recognition, cleavage, and/or integration of foreign nucleic acids into CRISPRs. Short Name:  CRISPR-assoc_Cas1
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8 Child Features

DB identifier Type Name
IPR019851 Family CRISPR-associated protein Cas1, ECOLI subtype
IPR019855 Family CRISPR-associated protein Cas1, NMENI subtype
IPR019856 Family CRISPR-associated protein Cas1, DVULG subtype
IPR019857 Family CRISPR-associated protein Cas1, YPEST subtype
IPR019858 Family CRISPR-associated protein Cas1, HMARI/TNEAP subtype
IPR023843 Family CRISPR-associated protein Cas1, cyanobacteria-type
IPR023844 Family CRISPR-associated protein Cas1, MYXAN subtype
IPR027617 Family CRISPR-associated endonuclease Cas1, PREFRAN subtype

0 Contains

3 Cross Referencess

Identifier
PF01867
TIGR00287
MF_01470

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            17442114
            17379808
            16545108
            19523907
            21699496
            24459147