3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0070976 | IPR017281 |
| GO:0002755 | IPR017281 |
| GO:0043123 | IPR017281 |
| Type: | Family | Name: | Myeloid differentiation primary response protein MyD88 |
| Description: | Myeloid differentiation primary response protein MyD88 is an intracellular adaptor protein that has an essential role in innate immune signalling. It is vital for the proper responses of interleukin-1 and interleukin-18 and nearly all toll-like receptors (except TLR3) in the activation of transcription factors NF-kappa B and AP-1 followed by the induction of pro-inflammatory genes []. MyD88 contains a TIR (Toll/Interleukin-1 receptor) domain and a death domain []. The TIR domain is important for the protein's interaction with receptors, while the death domain is involved in signal transduction. For example, MyD88 interacts with IL-1R-associated kinase (IRAK)-4 through its death domain, and in turn, IRAK-4 activates other members of the IRAK family, like IRAK-1 [].Defects in MYD88 are the cause of MYD88 deficiency [], also known as as recurrent pyogenic bacterial infections due to MYD88 deficiency. | Short Name: | Myelin_different_resp_MyD88 |
| GO Term | Gene Name |
|---|---|
| GO:0070976 | IPR017281 |
| GO:0002755 | IPR017281 |
| GO:0043123 | IPR017281 |
