Protein Domain : IPR027289

Type:  Family Name:  Oestrogen-related receptor
Description:  Oestrogen-related receptors (ERR-alpha, ERR-beta, and ERR-gamma) are orphan nuclear receptors whose physiological ligands have not yet been identified. ERRs are closely related to oestrogen receptors (ERs), and bind and regulate transcription via oestrogen response elements (EREs) and extended ERE half-sites termed ERR response elements (ERREs) []. However, they do not respond to oestrogens []. ERR-alpha has been shown to play a role in energy homeostasis [] and defects in ERR-beta are the cause of deafness autosomal recessive type 35 (DFNB35), which is a form of sensorineural hearing loss. []. Short Name:  Oest-rel_rcp
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0 Child Features

0 Contains

1 Cross References

Identifier
PIRSF500939

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0003677 IPR027289
GO:0003707 IPR027289
GO:0005496 IPR027289
GO:0006355 IPR027289
GO:0005634 IPR027289

5 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR027289
GO:0003707 IPR027289
GO:0005496 IPR027289
GO:0006355 IPR027289
GO:0005634 IPR027289

1 Parent Features

DB identifier Type Name
IPR024178 Family Oestrogen receptor/oestrogen-related receptor

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12185669
            16515477
            21731503
            18179891