| Type: | Family | Name: | Superoxide dismutase (Cu/Zn), extracellular |
| Description: | Superoxide dismutases are ubiquitous metalloproteins that prevent damage by oxygen-mediated free radicals by catalysing the dismutation of superoxideinto molecular oxygen and hydrogen peroxide []. Superoxide is a normal by-product of aerobic respiration and is produced by a number of reactions, including oxidative phosphorylation and photosynthesis. The dismutaseenzymes have a very high catalytic efficiency due to the attraction of superoxide to the ions bound at the active site [, ].There are three forms of superoxide dismutase, depending on the metal cofactor: Cu/Zn (which binds both copper and zinc), Fe and Mn types. The Fe and Mnforms are similar in their primary, secondary and tertiary structures, but are distinct from the Cu/Zn form []. Prokaryotes and protists contain Mn,Fe or both types, while most eukaryotic organisms utilise the Cu/Zn type.Extracellular super-oxide dismutases (EC-SOD) are copper and zinc binding glycoproteins of about 135,000 kDa, which are hydrophobic in nature []. Their function is to protect the extracellular space from stress by oxidants []. In some instances EC-SOD dimerises, though in many species four identical subunits of EC-SOD associate to form a tetramer. This entry represents EC-SOD from vertebrates. | Short Name: | SOD_Cu/Zn_extracel |
| GO Term | Gene Name |
|---|---|
| GO:0004784 | IPR024141 |
| GO:0005507 | IPR024141 |
| GO:0008270 | IPR024141 |
| GO:0006801 | IPR024141 |
| GO:0055114 | IPR024141 |
| GO Term | Gene Name |
|---|---|
| GO:0004784 | IPR024141 |
| GO:0005507 | IPR024141 |
| GO:0008270 | IPR024141 |
| GO:0006801 | IPR024141 |
| GO:0055114 | IPR024141 |
