Protein Domain : IPR030535

Type:  Family Name:  Double C2-like domain-containing protein alpha
Description:  Doc2a (double C2-like domain-containing protein alpha) is a member of the double C2 domain protein family. Doc2a is expressed in neuronal cells and has been implicated in Ca2+-dependent neurotransmitter release [, ]. Doc2a exhibits Ca2+-dependent phospholipid-binding activity through its C2A domain, which is thought to be important for the regulation of Ca2+-dependent exocytosis. The C2B domain is required for binding of syntaxin-1a/synaptosome-associated protein of 25 kDa (SNAP-25) heterodimer []. Doc2a is also expressed in pancreatic islets, and has been implicated together with Doc2b in the synergistic regulation of glucose-stimulated insulin secretion []. Short Name:  Doc2a
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10024:SF204

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005509 IPR030535
GO:0005544 IPR030535
GO:0007268 IPR030535
GO:0017158 IPR030535

4 Ontology Annotations

GO Term Gene Name
GO:0005509 IPR030535
GO:0005544 IPR030535
GO:0007268 IPR030535
GO:0017158 IPR030535

1 Parent Features

DB identifier Type Name
IPR014638 Family Double C2 protein, alpha/beta/gamma

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            25005332
            16515538
            22036572
            20403080