Protein Domain : IPR000747

Type:  Domain Name:  Homeodomain engrailed
Description:  Proteins that regulate developmental gene expression are nuclear proteins [] that containa conserved domain known as the homeobox, the flanking sequences of which differ considerably among different proteins. The homeodomain includes the helix-turn-helix (HTH) motif which binds to DNA[]. Most proteins which contain a homeobox domain can be classified [, ],on the basis of their sequence characteristics, into three subfamilies, engrailed, antennapedia and paired. The engrailed subfamily plays an important role in Drosophila segmentation and neurogenesis,affecting genes in posterior compartments of the developing embryo. It is also required for the development of the central nervous system. Homologues found in other species may play a role inneurogenesis, possibly in both the compartmentalisation of the developing neural tube and specification of particular neuronal populations. Other members of the engrailed subfamily include Drosophila invectedprotein (inv); Apis mellifera(Honeybee) E30 and E60; Schistocerca americana(American grasshopper) G-En; mammalian and birds En-1 and En-2; Danio rerio(Zebrafish) (Brachydanio rerio) Eng-1, -2 and -3; Helobdella triserialis(Leech) Ht-En; and Caenorhabditis elegansceh-16. Short Name:  Homeodomain_engrailed

0 Child Features

3 Contains

DB identifier Type Name
IPR000047 Conserved_site Helix-turn-helix motif
IPR017970 Conserved_site Homeobox, conserved site
IPR019737 Conserved_site Homeobox engrailed-type, conserved site

1 Cross References

Identifier
PR00026

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003677 IPR000747
GO:0007275 IPR000747
GO:0005634 IPR000747

3 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR000747
GO:0007275 IPR000747
GO:0005634 IPR000747

1 Parent Features

DB identifier Type Name
IPR020479 Domain Homeodomain, metazoa

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2568852
            2566559
            1970866
            2884726