Protein Domain : IPR017150

Type:  Family Name:  Peptidase M20, glutamate carboxypeptidase
Description:  Metalloproteases are the most diverse of the four main types of protease, with more than 50 families identified to date. In these enzymes, a divalent cation, usually zinc, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. The known metal ligands are His, Glu, Asp or Lys and at least one other residue is required for catalysis, which may play an electrophillic role. Of the known metalloproteases, around half contain an HEXXH motif, which has been shown in crystallographic studies to form part of the metal-binding site []. The HEXXH motif is relatively common, but can be more stringently defined for metalloproteases as 'abXHEbbHbc', where 'a' is most often valine or threonine and forms part of the S1' subsite in thermolysin and neprilysin, 'b' is an uncharged residue, and 'c' a hydrophobic residue. Proline is never found in this site, possibly because it would break the helical structure adopted by this motif in metalloproteases [].This group of proteins contains the metallopeptidases and non-peptidase homologues that belong to the MEROPS peptidase family M20 (clan MH) []. The peptidases of this clan have two catalytic zinc ions at the active site, bound by His/Asp, Asp, Glu, Asp/Glu and His. The catalysed reaction involves the release of an N-terminal aminoacid, usually neutral or hydrophobic, from a polypeptide []. The peptidases in this entry belong to the M20A sub-family: M20A - type example, glutamate carboxypeptidase from Pseudomonas sp. RS16(). Short Name:  Pept_M20_glutamate_carboxypep

0 Child Features

1 Contains

DB identifier Type Name
IPR011650 Domain Peptidase M20, dimerisation domain

1 Cross References

Identifier
PIRSF037238

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR002933 Family Peptidase M20

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7674922