1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR009045 | Domain | Hedgehog signalling/DD-peptidase zinc-binding domain |
| Type: | Domain | Name: | Hedgehog, N-terminal signalling domain |
| Description: | Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autolytic domain of the hedgehog protein of shows similarity with the beta-strand core of intein splicing domains. It has hence been termed the hint (Hedgehog/Intein) domain [].This entry represents the N-terminal domain of hedgehog proteins, which is responsible for signalling following cleavage from the C-terminal domain. Its structure has been solved, and reveals a tetrahedrally coordinated zinc ion that appears to be structurally analogous to the zinc coordination sites of zinc hydrolases, such as thermolysin and carboxypeptidase A []. This putative catalytic site represents a distinct activity from the autoprocessing activity that resides in the carboxy-terminal domain. | Short Name: | Hedgehog_signalling_dom |
| DB identifier | Type | Name |
|---|---|---|
| IPR009045 | Domain | Hedgehog signalling/DD-peptidase zinc-binding domain |
